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Target Snapshot

CHEMBL4801 Target Snapshot

Caspase-1 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
4,956Compounds
213Assays
5Approved Drugs
2,882.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Caspase-1 shows clinical signal disease relevance led by COVID-19. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P29466. Start with COVID-19, then reuse UniProt P29466 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with COVID-19, then reuse UniProt P29466 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
COVID-19

Caspase-1 shows clinical signal disease relevance led by COVID-19. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with COVID-19 because it currently carries clinical signal support. Linked drugs include BELNACASAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Caspase-1 as ChEMBL target CHEMBL4801, mapped to UniProt P29466. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Caspase-1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4801
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P29466
Caspase-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Caspase-1 is the right protein anchor across sources, using UniProt P29466 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why COVID-19 is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCaspase-1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP29466
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCaspase-1
UniProt AccessionP29466
Component TypeProtein
Sequence Length404 aa

Caspase-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Caspase-1, mapped to UniProt P29466. Sequence length is 404 aa.

Mapped IDP29466
Review nameCaspase-1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Caspase-1 shows clinical signal disease relevance led by COVID-19. 5 more disease programs remain visible in the same review block.

Clinical signal Phase II
COVID-19
1 linked drug · 1 direct · 1 efficacy
Linked drugBELNACASAN
Clinical signal Phase II
epilepsy
1 linked drug · 1 direct · 1 efficacy
Linked drugBELNACASAN
Clinical signal Phase II
hepatitis C virus infection
1 linked drug · 1 direct · 1 efficacy
Linked drugNIVOCASAN
Clinical signal Phase II
non-alcoholic steatohepatitis
1 linked drug · 1 direct · 1 efficacy
Linked drugNIVOCASAN
Clinical signal Phase II
partial epilepsy
1 linked drug · 1 direct · 1 efficacy
Linked drugBELNACASAN
Clinical signal Phase II
psoriasis
1 linked drug · 1 direct · 1 efficacy
Linked drugBELNACASAN
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with COVID-19 because it currently carries clinical signal support. Linked drugs include BELNACASAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseCOVID-19
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC501,656.0
KI1,210.0
EC5014.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL267338 9.96 IC50 0.11 Preclinical
CHEMBL26544 9.82 Ki 0.15 Preclinical
CHEMBL286519 9.82 Ki 0.15 Preclinical
CHEMBL553107 9.7 Ki 0.2 Preclinical
CHEMBL589552 9.7 IC50 0.2 Preclinical
CHEMBL111965 9.43 IC50 0.37 Preclinical
CHEMBL115090 9.43 Ki 0.37 Preclinical
CHEMBL112207 9.4 IC50 0.4 Preclinical
CHEMBL1221597 9.24 Ki 0.58 Preclinical
CHEMBL437105 9.22 Ki 0.6 Preclinical
Distribution

pChEMBL Value Distribution

109
5.0
123
5.5
118
6.0
84
6.5
113
7.0
79
7.5
85
8.0
48
8.5
37
9.0
5
9.5
pChEMBL
Approved Drugs

Approved Drugs

CANNABIDIOL
CHEMBL190461
Approved 2018
Properties Compare Identifier
Assay Landscape

Assay Landscape

214
Total Assays
788
Tested Compounds
2
Assay Types
Binding — 201 assays, 788 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 160 652 6.6
cell-based format 27 61 5.5
assay format 10 73 6.7
tissue-based format 3 2 5.6
biochemical format 1 0 —
Functional — 13 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 13 3 7.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine