Kallikrein-8 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O60259. Use UniProt O60259 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O60259 as the stable identity anchor, then attach disease evidence before program review.
Kallikrein-8
Review this target as Kallikrein-8, mapped to UniProt O60259. Sequence length is 260 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Kallikrein-8 as ChEMBL target CHEMBL4812, mapped to UniProt O60259. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Kallikrein-8 is the right protein anchor across sources, using UniProt O60259 as the stable mapping.
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| Preferred Name | Kallikrein-8 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O60259 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Kallikrein-8 |
| UniProt Accession | O60259 |
| Component Type | Protein |
| Sequence Length | 260 aa |
Kallikrein-8
Review this target as Kallikrein-8, mapped to UniProt O60259. Sequence length is 260 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4558285 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL4447752 | 7.6 | IC50 | 25.12 | Preclinical |
| CHEMBL4465265 | 7.5 | IC50 | 31.62 | Preclinical |
| CHEMBL4517343 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL239331 | 6.9 | IC50 | 125.0 | Preclinical |
| CHEMBL239535 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL3770794 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL4436048 | 6.7 | IC50 | 199.53 | Preclinical |
| CHEMBL4206734 | 6.68 | IC50 | 210.0 | Preclinical |
| CHEMBL4461533 | 6.6 | IC50 | 251.19 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 1 | 5.0 |
| assay format | 4 | 8 | 6.3 |
| cell-based format | 1 | 15 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 6.1 |