Sodium/potassium-transporting ATPase subunit alpha-1 · SINGLE PROTEIN · Canis lupus familiaris
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As of 2026-09-14Protein identity stays anchored to UniProt P50997. Use UniProt P50997 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P50997 as the stable identity anchor, then attach disease evidence before program review.
Sodium/potassium-transporting ATPase subunit alpha-1
Review this target as Sodium/potassium-transporting ATPase subunit alpha-1, mapped to UniProt P50997. Sequence length is 1021 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium/potassium-transporting ATPase subunit alpha-1 as ChEMBL target CHEMBL4838, mapped to UniProt P50997. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sodium/potassium-transporting ATPase subunit alpha-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
| UniProt | P50997 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium/potassium-transporting ATPase subunit alpha-1 |
| UniProt Accession | P50997 |
| Component Type | Protein |
| Sequence Length | 1021 aa |
Sodium/potassium-transporting ATPase subunit alpha-1
Review this target as Sodium/potassium-transporting ATPase subunit alpha-1, mapped to UniProt P50997. Sequence length is 1021 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL254219 | 8.1 | IC50 | 8.0 | Approved |
| CHEMBL2069115 | 8.08 | IC50 | 8.3 | Preclinical |
| CHEMBL2069118 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL2069066 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL2069075 | 7.34 | IC50 | 45.5 | Preclinical |
| CHEMBL469045 | 6.85 | IC50 | 140.0 | Preclinical |
| CHEMBL2068996 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL2069070 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL2068890 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL2068972 | 6.5 | IC50 | 320.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 19 | 5.6 |
| microsome format | 1 | 11 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 6.8 |