CX3C chemokine receptor 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P49238. Use UniProt P49238 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49238 as the stable identity anchor, then attach disease evidence before program review.
CX3C chemokine receptor 1
Review this target as CX3C chemokine receptor 1, mapped to UniProt P49238. Sequence length is 355 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats CX3C chemokine receptor 1 as ChEMBL target CHEMBL4843, mapped to UniProt P49238. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether CX3C chemokine receptor 1 is the right protein anchor across sources, using UniProt P49238 as the stable mapping.
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| Preferred Name | CX3C chemokine receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P49238 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | CX3C chemokine receptor 1 |
| UniProt Accession | P49238 |
| Component Type | Protein |
| Sequence Length | 355 aa |
CX3C chemokine receptor 1
Review this target as CX3C chemokine receptor 1, mapped to UniProt P49238. Sequence length is 355 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2349310 | 8.41 | Ki | 3.9 | Clinical |
| CHEMBL2349322 | 8.4 | Ki | 4.0 | Preclinical |
| CHEMBL4518556 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL2349316 | 8.33 | Ki | 4.7 | Preclinical |
| CHEMBL4539605 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL2349180 | 8.24 | Ki | 5.8 | Preclinical |
| CHEMBL4577003 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL4474066 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL2349179 | 8.21 | Ki | 6.2 | Preclinical |
| CHEMBL2349312 | 8.11 | Ki | 7.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 0 | — |
| cell-based format | 8 | 64 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 0 | — |
| cell-based format | 1 | 20 | 5.6 |
| single protein format | 1 | 0 | — |