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Target Snapshot

CHEMBL4845615 Target Snapshot

Saphenous artery · TISSUE · Oryctolagus cuniculus

28Compounds
5Assays
2Approved Drugs
31.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Saphenous artery as ChEMBL target CHEMBL4845615. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Saphenous artery
TISSUE · Oryctolagus cuniculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4845615
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSaphenous artery
UniProt AccessionN/A

Saphenous artery

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Saphenous artery.

Review nameSaphenous artery
OrganismOryctolagus cuniculus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5031.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL730 8.72 IC50 1.9 Approved
CHEMBL4066936 8.25 IC50 5.6 Approved
CHEMBL5270382 7.7 IC50 20.0 Preclinical
CHEMBL5722966 7.25 IC50 56.0 Preclinical
CHEMBL1971943 7.19 IC50 65.0 Preclinical
CHEMBL5722984 7.09 IC50 82.0 Preclinical
CHEMBL5723002 7.08 IC50 84.0 Preclinical
CHEMBL5723015 7.05 IC50 89.0 Preclinical
CHEMBL5428272 7.0 IC50 100.0 Preclinical
CHEMBL4650322 6.7 IC50 199.0 Clinical
Distribution

pChEMBL Value Distribution

1
5.0
4
5.5
8
6.0
3
6.5
6
7.0
1
7.5
3
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VERICIGUAT
CHEMBL4066936
Approved 2021
NITROGLYCERIN
CHEMBL730
Approved 1981
Assay Landscape

Assay Landscape

5
Total Assays
24
Tested Compounds
1
Assay Types
Functional — 5 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 2 7.9
tissue-based format 2 22 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine