Serine/threonine-protein kinase Nek7 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8TDX7. Use UniProt Q8TDX7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8TDX7 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase Nek7
Review this target as Serine/threonine-protein kinase Nek7, mapped to UniProt Q8TDX7. Sequence length is 302 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase Nek7 as ChEMBL target CHEMBL4849, mapped to UniProt Q8TDX7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase Nek7 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8TDX7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase Nek7 |
| UniProt Accession | Q8TDX7 |
| Component Type | Protein |
| Sequence Length | 302 aa |
Serine/threonine-protein kinase Nek7
Review this target as Serine/threonine-protein kinase Nek7, mapped to UniProt Q8TDX7. Sequence length is 302 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL281948 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL475251 | 7.96 | Kd | 11.0 | Clinical |
| CHEMBL5653589 | 6.81 | Kd | 156.41 | Preclinical |
| CHEMBL1287853 | 6.8 | Kd | 160.0 | Approved |
| CHEMBL1908397 | 6.68 | Kd | 210.0 | Preclinical |
| CHEMBL5750400 | 6.65 | IC50 | 225.0 | Clinical |
| CHEMBL5768122 | 6.65 | IC50 | 225.0 | Preclinical |
| CHEMBL5870995 | 6.65 | IC50 | 225.0 | Preclinical |
| CHEMBL5887510 | 6.65 | IC50 | 225.0 | Preclinical |
| CHEMBL5904011 | 6.65 | IC50 | 225.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 186 | 19 | 5.8 |
| cell-based format | 31 | 27 | 6.3 |
| subcellular format | 25 | 2 | 7.1 |
| assay format | 19 | 0 | — |
| tissue-based format | 10 | 1 | 5.1 |