DNA polymerase catalytic subunit · SINGLE PROTEIN · Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
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As of 2026-09-14DNA polymerase catalytic subunit shows clinical signal disease relevance led by Herpes Zoster. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P09252. Start with Herpes Zoster, then reuse UniProt P09252 as the stable protein anchor across project notes and exports.
Start with Herpes Zoster, then reuse UniProt P09252 as the stable protein anchor across project notes and exports.
DNA polymerase catalytic subunit shows clinical signal disease relevance led by Herpes Zoster. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Herpes Zoster because it currently carries clinical signal support. Linked drugs include SORIVUDINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDNA polymerase catalytic subunit
Review this target as DNA polymerase catalytic subunit, mapped to UniProt P09252. Sequence length is 1194 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA polymerase catalytic subunit as ChEMBL target CHEMBL4859, mapped to UniProt P09252. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether DNA polymerase catalytic subunit is the right protein anchor across sources, using UniProt P09252 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Herpes Zoster is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | DNA polymerase catalytic subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
| UniProt | P09252 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA polymerase catalytic subunit |
| UniProt Accession | P09252 |
| Component Type | Protein |
| Sequence Length | 1194 aa |
DNA polymerase catalytic subunit
Review this target as DNA polymerase catalytic subunit, mapped to UniProt P09252. Sequence length is 1194 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
DNA polymerase catalytic subunit shows clinical signal disease relevance led by Herpes Zoster. 1 more disease program remain visible in the same review block.
Start review with Herpes Zoster because it currently carries clinical signal support. Linked drugs include SORIVUDINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL363625 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL194433 | 6.43 | IC50 | 370.0 | Preclinical |
| CHEMBL195453 | 6.34 | IC50 | 460.0 | Preclinical |
| CHEMBL29711 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL440033 | 6.11 | IC50 | 770.0 | Preclinical |
| CHEMBL193952 | 5.24 | IC50 | 5800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 6 | 6.0 |