Use UniProt Q96G91 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4867 Target Snapshot
P2Y purinoceptor 11 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q96G91. Use UniProt Q96G91 as the stable identity anchor, then attach disease evidence before program review.
P2Y purinoceptor 11
Review this target as P2Y purinoceptor 11, mapped to UniProt Q96G91. Sequence length is 374 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats P2Y purinoceptor 11 as ChEMBL target CHEMBL4867, mapped to UniProt Q96G91. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | P2Y purinoceptor 11 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q96G91 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | P2Y purinoceptor 11 |
| UniProt Accession | Q96G91 |
| Component Type | Protein |
| Sequence Length | 374 aa |
P2Y purinoceptor 11
How to read this target
Review this target as P2Y purinoceptor 11, mapped to UniProt Q96G91. Sequence length is 374 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5289838 | 7.8 | Ki | 15.85 | Preclinical |
| CHEMBL413145 | 7.35 | Ki | 44.67 | Preclinical |
| CHEMBL131890 | 7.2 | EC50 | 63.1 | Preclinical |
| CHEMBL413910 | 7.12 | Ki | 75.86 | Preclinical |
| CHEMBL413180 | 6.97 | Ki | 107.15 | Preclinical |
| CHEMBL265502 | 6.95 | Ki | 112.2 | Clinical |
| CHEMBL2386496 | 6.89 | EC50 | 130.0 | Preclinical |
| CHEMBL266646 | 6.52 | Ki | 302.0 | Preclinical |
| CHEMBL405500 | 6.35 | Ki | 446.68 | Preclinical |
| CHEMBL413145 | 6.34 | IC50 | 457.09 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Functional — 31 assays, 30 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 22 | 20 | 5.7 |
| assay format | 9 | 10 | 4.9 |
Binding — 10 assays, 11 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 1 | 7.8 |
| cell-based format | 4 | 9 | 6.5 |
| assay format | 1 | 1 | 6.3 |