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Target Snapshot

CHEMBL4867 Target Snapshot

P2Y purinoceptor 11 · SINGLE PROTEIN · Homo sapiens

84Compounds
41Assays
1Approved Drugs
70.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q96G91. Use UniProt Q96G91 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96G91 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats P2Y purinoceptor 11 as ChEMBL target CHEMBL4867, mapped to UniProt Q96G91. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
P2Y purinoceptor 11
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4867
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q96G91
P2Y purinoceptor 11
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether P2Y purinoceptor 11 is the right protein anchor across sources, using UniProt Q96G91 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelP2Y purinoceptor 11
UniProt AccessionQ96G91
Component TypeProtein
Sequence Length374 aa

P2Y purinoceptor 11

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as P2Y purinoceptor 11, mapped to UniProt Q96G91. Sequence length is 374 aa.

Mapped IDQ96G91
Review nameP2Y purinoceptor 11
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase III
1
Phase II
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC503.0
KI16.0
EC5051.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5289838 7.8 Ki 15.85 Preclinical
CHEMBL413145 7.35 Ki 44.67 Preclinical
CHEMBL131890 7.2 EC50 63.1 Preclinical
CHEMBL413910 7.12 Ki 75.86 Preclinical
CHEMBL413180 6.97 Ki 107.15 Preclinical
CHEMBL265502 6.95 Ki 112.2 Clinical
CHEMBL2386496 6.89 EC50 130.0 Preclinical
CHEMBL266646 6.52 Ki 302.0 Preclinical
CHEMBL405500 6.35 Ki 446.68 Preclinical
CHEMBL413145 6.34 IC50 457.09 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
12
5.5
10
6.0
5
6.5
3
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

41
Total Assays
30
Tested Compounds
2
Assay Types
Functional — 31 assays, 30 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 20 5.7
assay format 9 10 4.9
Binding — 10 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 1 7.8
cell-based format 4 9 6.5
assay format 1 1 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine