Cytochrome P450 1B1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q16678. Use UniProt Q16678 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16678 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 1B1
Review this target as Cytochrome P450 1B1, mapped to UniProt Q16678. Sequence length is 543 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 1B1 as ChEMBL target CHEMBL4878, mapped to UniProt Q16678. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 1B1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16678 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 1B1 |
| UniProt Accession | Q16678 |
| Component Type | Protein |
| Sequence Length | 543 aa |
Cytochrome P450 1B1
Review this target as Cytochrome P450 1B1, mapped to UniProt Q16678. Sequence length is 543 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5560596 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL5557701 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL5575235 | 10.66 | Ki | 0.02171 | Preclinical |
| CHEMBL5575235 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL3421639 | 10.37 | IC50 | 0.043 | Preclinical |
| CHEMBL4749123 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL5279681 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL4798651 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL5561280 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL3422257 | 9.7 | IC50 | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 45 | 144 | 6.7 |
| cell-based format | 41 | 48 | 6.5 |
| single protein format | 27 | 232 | 7.8 |
| cell membrane format | 7 | 24 | 7.0 |
| microsome format | 4 | 2 | 8.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 45 | 131 | 7.5 |
| cell-based format | 17 | 39 | 6.7 |
| assay format | 9 | 9 | 5.9 |
| cell membrane format | 3 | 29 | 6.5 |
| microsome format | 2 | 0 | — |