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Target Snapshot

CHEMBL4879431 Target Snapshot

Alpha-1-antitrypsin-related protein · SINGLE PROTEIN · Homo sapiens

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12Compounds
5Assays
0Approved Drugs
11.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P20848. Use UniProt P20848 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P20848 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alpha-1-antitrypsin-related protein as ChEMBL target CHEMBL4879431, mapped to UniProt P20848. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alpha-1-antitrypsin-related protein
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4879431
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P20848
Alpha-1-antitrypsin-related protein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alpha-1-antitrypsin-related protein is the right protein anchor across sources, using UniProt P20848 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAlpha-1-antitrypsin-related protein
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP20848
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAlpha-1-antitrypsin-related protein
UniProt AccessionP20848
Component TypeProtein
Sequence Length421 aa

Alpha-1-antitrypsin-related protein

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Alpha-1-antitrypsin-related protein, mapped to UniProt P20848. Sequence length is 421 aa.

Mapped IDP20848
Review nameAlpha-1-antitrypsin-related protein
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5011.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3989870 9.7 IC50 0.2 Clinical
CHEMBL5596626 7.7 IC50 20.0 Preclinical
CHEMBL4875626 6.19 IC50 641.0 Preclinical
CHEMBL4851439 5.63 IC50 2360.0 Preclinical
CHEMBL4860779 5.54 IC50 2890.0 Preclinical
CHEMBL4849035 5.39 IC50 4080.0 Preclinical
CHEMBL4850640 5.22 IC50 6000.0 Preclinical
CHEMBL4871998 5.21 IC50 6160.0 Preclinical
CHEMBL4873263 5.08 IC50 8300.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
2
5.5
1
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
9
Tested Compounds
2
Assay Types
Binding — 3 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 2 8.7
cell-based format 1 7 5.5
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine