Protein cereblon/Cyclin-dependent kinase 12 · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9NYV4. Use UniProt Q9NYV4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NYV4 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-dependent kinase 12
Review this target as Protein cereblon/Cyclin-dependent kinase 12, mapped to UniProt Q9NYV4. ChEMBL maps the protein component as Cyclin-dependent kinase 12. Sequence length is 1490 aa.
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This review treats Protein cereblon/Cyclin-dependent kinase 12 as ChEMBL target CHEMBL4879535, mapped to UniProt Q9NYV4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Protein cereblon/Cyclin-dependent kinase 12 |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | Q9NYV4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-dependent kinase 12 |
| UniProt Accession | Q9NYV4 |
| Component Type | Protein |
| Sequence Length | 1490 aa |
Cyclin-dependent kinase 12
Review this target as Protein cereblon/Cyclin-dependent kinase 12, mapped to UniProt Q9NYV4. ChEMBL maps the protein component as Cyclin-dependent kinase 12. Sequence length is 1490 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5178057 | 8.66 | EC50 | 2.2 | Preclinical |
| CHEMBL5184280 | 8.41 | EC50 | 3.9 | Preclinical |
| CHEMBL5200971 | 8.36 | EC50 | 4.4 | Preclinical |
| CHEMBL5182667 | 8.26 | EC50 | 5.5 | Preclinical |
| CHEMBL5420004 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5205494 | 8.17 | EC50 | 6.8 | Preclinical |
| CHEMBL5424163 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL5193459 | 7.71 | EC50 | 19.3 | Preclinical |
| CHEMBL5179163 | 7.48 | EC50 | 33.1 | Preclinical |
| CHEMBL5186403 | 7.45 | EC50 | 35.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 19 | 11 | 8.0 |
| protein format | 1 | 0 | — |