Dihydrofolate reductase · SINGLE PROTEIN · Salmonella enterica subsp. enterica serovar Typhi
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt Q8Z9J9. Use UniProt Q8Z9J9 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8Z9J9 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt Q8Z9J9. Sequence length is 159 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL4888, mapped to UniProt Q8Z9J9. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Dihydrofolate reductase is the right protein anchor across sources, using UniProt Q8Z9J9 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Salmonella enterica subsp. enterica serovar Typhi |
| UniProt | Q8Z9J9 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | Q8Z9J9 |
| Component Type | Protein |
| Sequence Length | 159 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt Q8Z9J9. Sequence length is 159 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL32039 | 8.35 | Ki | 4.467 | Clinical |
| CHEMBL31891 | 8.18 | Ki | 6.607 | Clinical |
| CHEMBL57787 | 8.12 | Ki | 7.586 | Preclinical |
| CHEMBL22 | 8.08 | Ki | 8.318 | Approved |
| CHEMBL56318 | 8.07 | Ki | 8.511 | Clinical |
| CHEMBL53516 | 7.96 | Ki | 10.96 | Preclinical |
| CHEMBL57582 | 7.82 | Ki | 15.14 | Preclinical |
| CHEMBL56757 | 7.77 | Ki | 16.98 | Preclinical |
| CHEMBL19633 | 7.72 | Ki | 19.05 | Clinical |
| CHEMBL287241 | 7.71 | Ki | 19.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 58 | 7.0 |