Replicase polyprotein 1ab · SINGLE PROTEIN · Human coronavirus 229E
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As of 2026-09-13Protein identity stays anchored to UniProt P0C6X1. Use UniProt P0C6X1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0C6X1 as the stable identity anchor, then attach disease evidence before program review.
Replicase polyprotein 1ab
Review this target as Replicase polyprotein 1ab, mapped to UniProt P0C6X1. Sequence length is 6758 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Replicase polyprotein 1ab as ChEMBL target CHEMBL4888440, mapped to UniProt P0C6X1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Replicase polyprotein 1ab |
| Target Type | SINGLE PROTEIN |
| Organism | Human coronavirus 229E |
| UniProt | P0C6X1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Replicase polyprotein 1ab |
| UniProt Accession | P0C6X1 |
| Component Type | Protein |
| Sequence Length | 6758 aa |
Replicase polyprotein 1ab
Review this target as Replicase polyprotein 1ab, mapped to UniProt P0C6X1. Sequence length is 6758 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5182995 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL5173582 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL2365410 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5183165 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL4802135 | 6.84 | IC50 | 145.0 | Approved |
| CHEMBL586628 | 6.73 | IC50 | 186.21 | Preclinical |
| CHEMBL5185801 | 6.62 | IC50 | 239.0 | Preclinical |
| CHEMBL5173858 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL5612402 | 6.5 | IC50 | 320.0 | Preclinical |
| CHEMBL5612841 | 6.46 | IC50 | 350.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 7 | 7.0 |
| single protein format | 2 | 8 | 6.3 |