c-Jun N-terminal kinase · PROTEIN FAMILY · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q91Y86. Use UniProt Q91Y86 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q91Y86 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 8
Review this target as c-Jun N-terminal kinase, mapped to UniProt Q91Y86. ChEMBL maps the protein component as Mitogen-activated protein kinase 8. Sequence length is 384 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats c-Jun N-terminal kinase as ChEMBL target CHEMBL4888451, mapped to UniProt Q91Y86. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether c-Jun N-terminal kinase is the right protein anchor across sources, using UniProt Q91Y86 as the stable mapping.
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| Preferred Name | c-Jun N-terminal kinase |
| Target Type | PROTEIN FAMILY |
| Organism | Mus musculus |
| UniProt | Q91Y86 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 8 |
| UniProt Accession | Q91Y86 |
| Component Type | Protein |
| Sequence Length | 384 aa |
Mitogen-activated protein kinase 8
Review this target as c-Jun N-terminal kinase, mapped to UniProt Q91Y86. ChEMBL maps the protein component as Mitogen-activated protein kinase 8. Sequence length is 384 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4847106 | 6.3 | IC50 | 500.0 | Clinical |
| CHEMBL1950289 | 5.85 | IC50 | 1400.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 15 | 0 | — |
| tissue-based format | 4 | 2 | 5.6 |
| organism-based format | 1 | 0 | — |