MAP2K3/Myc proto-oncogene protein · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P46734. Use UniProt P46734 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P46734 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity mitogen-activated protein kinase kinase 3
Review this target as MAP2K3/Myc proto-oncogene protein, mapped to UniProt P46734. ChEMBL maps the protein component as Dual specificity mitogen-activated protein kinase kinase 3. Sequence length is 347 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats MAP2K3/Myc proto-oncogene protein as ChEMBL target CHEMBL4888452, mapped to UniProt P46734. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether MAP2K3/Myc proto-oncogene protein is the right protein anchor across sources, using UniProt P46734 as the stable mapping.
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| Preferred Name | MAP2K3/Myc proto-oncogene protein |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | P46734 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity mitogen-activated protein kinase kinase 3 |
| UniProt Accession | P46734 |
| Component Type | Protein |
| Sequence Length | 347 aa |
Dual specificity mitogen-activated protein kinase kinase 3
Review this target as MAP2K3/Myc proto-oncogene protein, mapped to UniProt P46734. ChEMBL maps the protein component as Dual specificity mitogen-activated protein kinase kinase 3. Sequence length is 347 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2336409 | 5.42 | IC50 | 3800.0 | Preclinical |
| CHEMBL275938 | 4.85 | IC50 | 14060.0 | Preclinical |
| CHEMBL101309 | 4.2 | IC50 | 63880.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 3 | 4.9 |
| protein format | 1 | 1 | 5.0 |