CDK8/CDK19 · PROTEIN FAMILY · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q8R3L8. Use UniProt Q8R3L8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8R3L8 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-dependent kinase 8
Review this target as CDK8/CDK19, mapped to UniProt Q8R3L8. ChEMBL maps the protein component as Cyclin-dependent kinase 8. Sequence length is 464 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats CDK8/CDK19 as ChEMBL target CHEMBL4888455, mapped to UniProt Q8R3L8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | CDK8/CDK19 |
| Target Type | PROTEIN FAMILY |
| Organism | Mus musculus |
| UniProt | Q8R3L8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-dependent kinase 8 |
| UniProt Accession | Q8R3L8 |
| Component Type | Protein |
| Sequence Length | 464 aa |
Cyclin-dependent kinase 8
Review this target as CDK8/CDK19, mapped to UniProt Q8R3L8. ChEMBL maps the protein component as Cyclin-dependent kinase 8. Sequence length is 464 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3408213 | 7.7 | EC50 | 20.0 | Preclinical |
| CHEMBL4225966 | 7.7 | EC50 | 20.0 | Preclinical |
| CHEMBL2348353 | 7.6 | EC50 | 25.0 | Preclinical |
| CHEMBL4076837 | 7.3 | EC50 | 50.0 | Preclinical |
| CHEMBL2348339 | 6.75 | EC50 | 180.0 | Preclinical |
| CHEMBL4226806 | 6.3 | EC50 | 500.0 | Preclinical |
| CHEMBL1409708 | 5.92 | EC50 | 1200.0 | Preclinical |
| CHEMBL4792423 | 5.77 | EC50 | 1700.0 | Preclinical |
| CHEMBL4780986 | 5.55 | EC50 | 2800.0 | Preclinical |
| CHEMBL4785945 | 4.96 | EC50 | 11000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 2 | 11 | 6.4 |