Mitogen-activated protein kinase kinase kinase 8 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Mitogen-activated protein kinase kinase kinase 8 shows clinical signal disease relevance led by ulcerative colitis. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P41279. Start with ulcerative colitis, then reuse UniProt P41279 as the stable protein anchor across project notes and exports.
Start with ulcerative colitis, then reuse UniProt P41279 as the stable protein anchor across project notes and exports.
Mitogen-activated protein kinase kinase kinase 8 shows clinical signal disease relevance led by ulcerative colitis. 1 linked drug remains visible in the same block.
Start review with ulcerative colitis because it currently carries clinical signal support. Linked drugs include TILPISERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMitogen-activated protein kinase kinase kinase 8
Review this target as Mitogen-activated protein kinase kinase kinase 8, mapped to UniProt P41279. Sequence length is 467 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 8 as ChEMBL target CHEMBL4899, mapped to UniProt P41279. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Mitogen-activated protein kinase kinase kinase 8 is the right protein anchor across sources, using UniProt P41279 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why ulcerative colitis is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 8 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P41279 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 8 |
| UniProt Accession | P41279 |
| Component Type | Protein |
| Sequence Length | 467 aa |
Mitogen-activated protein kinase kinase kinase 8
Review this target as Mitogen-activated protein kinase kinase kinase 8, mapped to UniProt P41279. Sequence length is 467 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mitogen-activated protein kinase kinase kinase 8 shows clinical signal disease relevance led by ulcerative colitis.
Start review with ulcerative colitis because it currently carries clinical signal support. Linked drugs include TILPISERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL527026 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL230117 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL371658 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL498071 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL498029 | 8.66 | IC50 | 2.2 | Preclinical |
| CHEMBL219682 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL221221 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL482863 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3912476 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL498070 | 8.4 | IC50 | 4.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 112 | 196 | 6.6 |
| assay format | 7 | 1 | 5.9 |
| cell-based format | 5 | 29 | 6.8 |
| subcellular format | 1 | 0 | — |
| tissue-based format | 1 | 6 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 17 | 6.2 |
| cell-based format | 1 | 0 | — |