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Target Snapshot

CHEMBL4900 Target Snapshot

Serine/threonine-protein kinase D2 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
2,157Compounds
357Assays
15Approved Drugs
1,238.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9BZL6. Use UniProt Q9BZL6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9BZL6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase D2 as ChEMBL target CHEMBL4900, mapped to UniProt Q9BZL6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase D2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4900
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9BZL6
Serine/threonine-protein kinase D2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase D2 is the right protein anchor across sources, using UniProt Q9BZL6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSerine/threonine-protein kinase D2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9BZL6
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase D2
UniProt AccessionQ9BZL6
Component TypeProtein
Sequence Length878 aa

Serine/threonine-protein kinase D2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase D2, mapped to UniProt Q9BZL6. Sequence length is 878 aa.

Mapped IDQ9BZL6
Review nameSerine/threonine-protein kinase D2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

15
Approved
9
Phase III
20
Phase II
24
Phase I
Assay Mix

Activity Type Distribution

IC50104.0
KI767.0
KD367.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1215000 9.0 IC50 1.0 Preclinical
CHEMBL1215151 9.0 IC50 1.0 Preclinical
CHEMBL388978 8.88 IC50 1.33 Preclinical
CHEMBL5897911 8.71 IC50 1.93 Preclinical
CHEMBL1214998 8.7 IC50 2.0 Preclinical
CHEMBL1215153 8.7 IC50 2.0 Preclinical
CHEMBL1215219 8.7 IC50 2.0 Preclinical
CHEMBL5419827 8.7 IC50 2.0 Preclinical
CHEMBL5428541 8.6 IC50 2.5 Preclinical
CHEMBL1980995 8.6 Ki 2.512 Preclinical
Distribution

pChEMBL Value Distribution

122
5.0
148
5.5
90
6.0
64
6.5
41
7.0
20
7.5
16
8.0
11
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MOMELOTINIB
CHEMBL1078178
Approved 2023
Properties Compare Identifier
BRIGATINIB
CHEMBL3545311
Approved 2017
Properties Compare Identifier
NINTEDANIB
CHEMBL502835
Approved 2014
Properties Compare Identifier
DABRAFENIB
CHEMBL2028663
Approved 2013
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

357
Total Assays
346
Tested Compounds
2
Assay Types
Binding — 356 assays, 147 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 264 92 6.9
assay format 44 0 —
cell-based format 26 11 7.0
subcellular format 22 44 6.0
Functional — 1 assays, 346 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 346 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine