Ephrin type-B receptor 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P54753. Use UniProt P54753 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54753 as the stable identity anchor, then attach disease evidence before program review.
Ephrin type-B receptor 3
Review this target as Ephrin type-B receptor 3, mapped to UniProt P54753. Sequence length is 998 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ephrin type-B receptor 3 as ChEMBL target CHEMBL4901, mapped to UniProt P54753. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ephrin type-B receptor 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P54753 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ephrin type-B receptor 3 |
| UniProt Accession | P54753 |
| Component Type | Protein |
| Sequence Length | 998 aa |
Ephrin type-B receptor 3
Review this target as Ephrin type-B receptor 3, mapped to UniProt P54753. Sequence length is 998 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL400402 | 8.7 | Kd | 2.0 | Preclinical |
| CHEMBL3752910 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5416410 | 8.16 | Kd | 6.9 | Approved |
| CHEMBL3321809 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL5191665 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL5203261 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL566515 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL1421 | 7.76 | IC50 | 17.4 | Approved |
| CHEMBL5202826 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL4638981 | 7.71 | IC50 | 19.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 228 | 56 | 6.0 |
| assay format | 31 | 1 | 8.2 |
| cell-based format | 13 | 8 | 7.5 |
| subcellular format | 6 | 14 | 5.9 |