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Evidence Snapshot

Trace amine-associated receptor 1

CHEMBL4908 SINGLE PROTEIN Mus musculus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T01:37:53Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4908
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trace amine-associated receptor 1 as ChEMBL target CHEMBL4908, mapped to UniProt Q923Y8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trace amine-associated receptor 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4908
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q923Y8
Trace amine-associated receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Trace amine-associated receptor 1 matters

As of 2026-09-14

Trace amine-associated receptor 1 is reviewed as Trace amine-associated receptor 1 (UniProt Q923Y8); the current evidence base includes 4 approved drugs, 2037 compounds, and 53 assays, with lead potency reaching pChEMBL 10.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 4 approved drugs, 2037 compounds, and 53 assays for this target. The dominant activity type is KI. CHEMBL3652713 is the current potency anchor at pChEMBL 10.0.

Use CHEMBL3652713 as the tractability anchor when discussing potency (pChEMBL 10.0).

Activity source · ChEMBL 36 via Core Engine
4 approved pChEMBL 10.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Trace amine-associated receptor 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q923Y8, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2037
Total Compounds
53
Total Assays
4
Approved Drugs
IC50: 201.0, KI: 2185.0, EC50: 139.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3652713
 10.0 Ki —
No preferred name
CHEMBL3656483
 10.0 Ki —
No preferred name
CHEMBL3680165
 10.0 Ki —
No preferred name
CHEMBL3652691
 9.7 Ki —
No preferred name
CHEMBL3656479
 9.7 Ki —

Approved Drugs

Structure Compound First Approval
DEXTROAMPHETAMINE
CHEMBL612
 1955
METHAMPHETAMINE
CHEMBL1201201
 1943
LEVAMFETAMINE
CHEMBL19393
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T01:37:53Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4908