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Target Snapshot

CHEMBL4914 Target Snapshot

Beta-ketoacyl-[acyl-carrier-protein] synthase III · SINGLE PROTEIN · Escherichia coli K-12

56Compounds
8Assays
1Approved Drugs
57.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0A6R0. Use UniProt P0A6R0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0A6R0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-ketoacyl-[acyl-carrier-protein] synthase III as ChEMBL target CHEMBL4914, mapped to UniProt P0A6R0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-ketoacyl-[acyl-carrier-protein] synthase III
SINGLE PROTEIN · Escherichia coli K-12
As of 2026-09-14
ChEMBL target ID
CHEMBL4914
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0A6R0
Beta-ketoacyl-[acyl-carrier-protein] synthase III
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-ketoacyl-[acyl-carrier-protein] synthase III is the right protein anchor across sources, using UniProt P0A6R0 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-ketoacyl-[acyl-carrier-protein] synthase III
UniProt AccessionP0A6R0
Component TypeProtein
Sequence Length317 aa

Beta-ketoacyl-[acyl-carrier-protein] synthase III

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Beta-ketoacyl-[acyl-carrier-protein] synthase III, mapped to UniProt P0A6R0. Sequence length is 317 aa.

Mapped IDP0A6R0
Review nameBeta-ketoacyl-[acyl-carrier-protein] synthase III
OrganismEscherichia coli K-12
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5047.0
KD10.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL458164 7.7 Kd 20.0 Preclinical
CHEMBL459369 5.91 Kd 1220.0 Preclinical
CHEMBL4100081 5.8 IC50 1600.0 Preclinical
CHEMBL4100896 5.7 IC50 2000.0 Preclinical
CHEMBL5555396 5.7 IC50 2000.0 Preclinical
CHEMBL4067921 5.46 IC50 3500.0 Preclinical
CHEMBL4065688 5.41 IC50 3900.0 Preclinical
CHEMBL4074137 5.41 IC50 3900.0 Preclinical
CHEMBL4088887 5.39 IC50 4100.0 Preclinical
CHEMBL4078806 5.37 IC50 4300.0 Preclinical
Distribution

pChEMBL Value Distribution

28
5.0
4
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
51
Tested Compounds
1
Assay Types
Binding — 8 assays, 51 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 6 20 4.9
assay format 2 31 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine