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Target Snapshot

CHEMBL4916 Target Snapshot

Fructose-bisphosphate aldolase, glycosomal · SINGLE PROTEIN · Trypanosoma brucei brucei

10Compounds
27Assays
0Approved Drugs
10.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P07752. Use UniProt P07752 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P07752 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fructose-bisphosphate aldolase, glycosomal as ChEMBL target CHEMBL4916, mapped to UniProt P07752. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fructose-bisphosphate aldolase, glycosomal
SINGLE PROTEIN · Trypanosoma brucei brucei
As of 2026-09-14
ChEMBL target ID
CHEMBL4916
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P07752
Fructose-bisphosphate aldolase, glycosomal
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fructose-bisphosphate aldolase, glycosomal is the right protein anchor across sources, using UniProt P07752 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFructose-bisphosphate aldolase, glycosomal
UniProt AccessionP07752
Component TypeProtein
Sequence Length372 aa

Fructose-bisphosphate aldolase, glycosomal

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Fructose-bisphosphate aldolase, glycosomal, mapped to UniProt P07752. Sequence length is 372 aa.

Mapped IDP07752
Review nameFructose-bisphosphate aldolase, glycosomal
OrganismTrypanosoma brucei brucei
Assay Mix

Activity Type Distribution

IC509.0
KI1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2017785 5.7 IC50 2000.0 Preclinical
CHEMBL258208 5.03 IC50 9400.0 Preclinical
CHEMBL1235112 5.0 IC50 10000.0 Preclinical
CHEMBL2017790 4.82 IC50 15000.0 Preclinical
CHEMBL382634 4.64 Ki 23030.0 Preclinical
CHEMBL2017788 4.51 IC50 31000.0 Preclinical
CHEMBL2017786 4.29 IC50 51000.0 Preclinical
CHEMBL2017791 4.25 IC50 56000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
1
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

27
Total Assays
10
Tested Compounds
1
Assay Types
Binding — 27 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 25 1 4.6
assay format 2 9 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine