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Evidence Snapshot

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

CHEMBL4931 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:42Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4931
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase as ChEMBL target CHEMBL4931, mapped to UniProt Q15125. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4931
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q15125
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase matters

As of 2026-09-13

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase is reviewed as 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (UniProt Q15125); the current evidence base includes 8 approved drugs, 123 compounds, and 20 assays, with lead potency reaching pChEMBL 9.2.

Protein context
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Sequence length is 230 aa.

Review this target as 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, mapped to UniProt Q15125. Sequence length is 230 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q15125 Protein
Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 8 approved drugs, 123 compounds, and 20 assays for this target. The dominant activity type is KI. CHEMBL17470 is the current potency anchor at pChEMBL 9.2.

Use CHEMBL17470 as the tractability anchor when discussing potency (pChEMBL 9.2).

Activity source · ChEMBL 36 via Core Engine
8 approved pChEMBL 9.2
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q15125, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

123
Total Compounds
20
Total Assays
8
Approved Drugs
IC50: 33.0, KI: 52.0, EC50: 13.0, KD: 2.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL17470
 9.2 Ki —
No preferred name
CHEMBL28211
 9.1 Ki Clinical
No preferred name
CHEMBL365842
 9.0 Ki —
No preferred name
CHEMBL62540
 9.0 Ki —
No preferred name
CHEMBL81
 9.0 Ki Approved

Approved Drugs

Structure Compound First Approval
RALOXIFENE
CHEMBL81
 1997
AMIODARONE
CHEMBL633
 1985
TAMOXIFEN
CHEMBL83
 1977
HALOPERIDOL
CHEMBL54
 1967
TRIFLUOPERAZINE
CHEMBL422
 1959
TRIPARANOL
CHEMBL187709
 —
BUFLOMEDIL
CHEMBL188921
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:42Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4931