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Target Snapshot

CHEMBL4944 Target Snapshot

Collagenase 3 · SINGLE PROTEIN · Rattus norvegicus

17Compounds
6Assays
0Approved Drugs
19.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P23097. Use UniProt P23097 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P23097 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Collagenase 3 as ChEMBL target CHEMBL4944, mapped to UniProt P23097. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Collagenase 3
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL4944
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P23097
Collagenase 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Collagenase 3 is the right protein anchor across sources, using UniProt P23097 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCollagenase 3
UniProt AccessionP23097
Component TypeProtein
Sequence Length466 aa

Collagenase 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Collagenase 3, mapped to UniProt P23097. Sequence length is 466 aa.

Mapped IDP23097
Review nameCollagenase 3
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

IC5019.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL7108 9.47 IC50 0.34 Preclinical
CHEMBL269019 9.12 IC50 0.75 Preclinical
CHEMBL427616 9.08 IC50 0.84 Preclinical
CHEMBL7756 8.72 IC50 1.9 Preclinical
CHEMBL6572 8.7 IC50 2.0 Preclinical
CHEMBL267939 8.68 IC50 2.1 Preclinical
CHEMBL268114 8.62 IC50 2.4 Preclinical
CHEMBL437017 8.59 IC50 2.56 Preclinical
CHEMBL7390 8.59 IC50 2.56 Preclinical
CHEMBL268377 8.54 IC50 2.9 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
4
8.0
7
8.5
4
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

6
Total Assays
14
Tested Compounds
1
Assay Types
Binding — 6 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 13 8.7
cell-free format 1 1 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine