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Target Snapshot

CHEMBL4953 Target Snapshot

Replication protein E1 · SINGLE PROTEIN · Human papillomavirus type 11

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51Compounds
2Assays
0Approved Drugs
53.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P04014. Use UniProt P04014 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P04014 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Replication protein E1 as ChEMBL target CHEMBL4953, mapped to UniProt P04014. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Replication protein E1
SINGLE PROTEIN · Human papillomavirus type 11
As of 2026-09-14
ChEMBL target ID
CHEMBL4953
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P04014
Replication protein E1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Replication protein E1 is the right protein anchor across sources, using UniProt P04014 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameReplication protein E1
Target TypeSINGLE PROTEIN
OrganismHuman papillomavirus type 11
UniProtP04014
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelReplication protein E1
UniProt AccessionP04014
Component TypeProtein
Sequence Length649 aa

Replication protein E1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Replication protein E1, mapped to UniProt P04014. Sequence length is 649 aa.

Mapped IDP04014
Review nameReplication protein E1
OrganismHuman papillomavirus type 11
Assay Mix

Activity Type Distribution

IC5052.0
KI1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL434551 8.37 IC50 4.3 Preclinical
CHEMBL176784 8.35 IC50 4.5 Preclinical
CHEMBL175099 8.04 IC50 9.2 Preclinical
CHEMBL174279 7.7 IC50 20.0 Preclinical
CHEMBL175280 7.57 IC50 27.0 Preclinical
CHEMBL368080 7.5 IC50 32.0 Preclinical
CHEMBL368100 7.37 IC50 43.0 Preclinical
CHEMBL172893 7.06 IC50 87.0 Preclinical
CHEMBL366522 7.06 IC50 87.0 Preclinical
CHEMBL178273 6.96 IC50 110.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
8
5.5
5
6.0
4
6.5
3
7.0
3
7.5
4
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
42
Tested Compounds
2
Assay Types
Binding — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 1 5.7
Functional — 1 assays, 42 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 42 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine