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Target Snapshot

CHEMBL4956 Target Snapshot

Gamma-aminobutyric acid receptor subunit alpha-2 · SINGLE PROTEIN · Homo sapiens

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189Compounds
25Assays
4Approved Drugs
157.0Activities
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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Gamma-aminobutyric acid receptor subunit alpha-2 shows approved-linked disease relevance led by anxiety. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P47869. Start with anxiety, then reuse UniProt P47869 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with anxiety, then reuse UniProt P47869 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 3 linked drugs
Open source guide
Disease program
anxiety

Gamma-aminobutyric acid receptor subunit alpha-2 shows approved-linked disease relevance led by anxiety. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with anxiety because it currently carries approved-linked support. Linked drugs include AZD6280, AZD7325, BROMAZEPAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Gamma-aminobutyric acid receptor subunit alpha-2 as ChEMBL target CHEMBL4956, mapped to UniProt P47869. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Gamma-aminobutyric acid receptor subunit alpha-2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4956
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P47869
Gamma-aminobutyric acid receptor subunit alpha-2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Gamma-aminobutyric acid receptor subunit alpha-2 is the right protein anchor across sources, using UniProt P47869 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why anxiety is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

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Evidence Card
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Overview

Basic Information

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Preferred NameGamma-aminobutyric acid receptor subunit alpha-2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP47869
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGamma-aminobutyric acid receptor subunit alpha-2
UniProt AccessionP47869
Component TypeProtein
Sequence Length451 aa

Gamma-aminobutyric acid receptor subunit alpha-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Gamma-aminobutyric acid receptor subunit alpha-2, mapped to UniProt P47869. Sequence length is 451 aa.

Mapped IDP47869
Review nameGamma-aminobutyric acid receptor subunit alpha-2
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Gamma-aminobutyric acid receptor subunit alpha-2 shows approved-linked disease relevance led by anxiety. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
anxiety
3 linked drugs · 3 direct · 3 efficacy
Linked drugAZD6280
Linked drugAZD7325
Linked drugBROMAZEPAM
Late clinical Phase III
Dementia
1 linked drug · 1 direct · 1 efficacy
Linked drugBROMAZEPAM
Late clinical Phase III
depressive disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugBROMAZEPAM
Late clinical Phase III
schizophrenia
1 linked drug · 1 direct · 1 efficacy
Linked drugBROMAZEPAM
Clinical signal Phase II
autism spectrum disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugAZD7325
Clinical signal Phase I
fragile X syndrome
1 linked drug · 1 direct · 1 efficacy
Linked drugAZD7325
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with anxiety because it currently carries approved-linked support. Linked drugs include AZD6280, AZD7325, BROMAZEPAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseanxiety
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

4
Approved
3
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5020.0
KI107.0
EC5030.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1783282 9.52 Ki 0.3 Clinical
CHEMBL44533 9.52 Ki 0.3 Preclinical
CHEMBL306422 9.24 Ki 0.58 Preclinical
CHEMBL45198 9.22 Ki 0.6 Preclinical
CHEMBL373250 9.15 Ki 0.7 Preclinical
CHEMBL363211 9.1 Ki 0.8 Preclinical
CHEMBL407 9.1 Ki 0.7943 Approved
CHEMBL49141 9.0 Ki 1.0 Preclinical
CHEMBL301605 9.0 Ki 1.0 Preclinical
CHEMBL5280240 9.0 Ki 1.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
4
5.5
14
6.0
32
6.5
27
7.0
36
7.5
19
8.0
5
8.5
9
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZOLPIDEM
CHEMBL911
Approved 1992
Properties Compare Identifier
FLUMAZENIL
CHEMBL407
Approved 1991
Properties Compare Identifier
ALPRAZOLAM
CHEMBL661
Approved 1981
Properties Compare Identifier
DIAZEPAM
CHEMBL12
Approved 1963
Properties Compare Identifier
Assay Landscape

Assay Landscape

25
Total Assays
144
Tested Compounds
3
Assay Types
Binding — 21 assays, 144 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 18 80 7.5
cell-based format 3 64 7.3
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine