Dynamin-1 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q05193. Use UniProt Q05193 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q05193 as the stable identity anchor, then attach disease evidence before program review.
Dynamin-1
Review this target as Dynamin-1, mapped to UniProt Q05193. Sequence length is 864 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dynamin-1 as ChEMBL target CHEMBL4958, mapped to UniProt Q05193. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dynamin-1 is the right protein anchor across sources, using UniProt Q05193 as the stable mapping.
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| Preferred Name | Dynamin-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q05193 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dynamin-1 |
| UniProt Accession | Q05193 |
| Component Type | Protein |
| Sequence Length | 864 aa |
Dynamin-1
Review this target as Dynamin-1, mapped to UniProt Q05193. Sequence length is 864 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5397838 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL5400843 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL1198288 | 5.82 | IC50 | 1500.0 | Preclinical |
| CHEMBL196854 | 5.77 | IC50 | 1700.0 | Preclinical |
| CHEMBL198466 | 5.77 | IC50 | 1700.0 | Preclinical |
| CHEMBL199469 | 5.77 | IC50 | 1700.0 | Preclinical |
| CHEMBL67535 | 5.77 | IC50 | 1700.0 | Preclinical |
| CHEMBL358746 | 5.68 | IC50 | 2100.0 | Preclinical |
| CHEMBL109458 | 5.5 | IC50 | 3150.0 | Preclinical |
| CHEMBL144589 | 5.5 | IC50 | 3200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 12 | 4.9 |
| assay format | 3 | 51 | 4.9 |
| single protein format | 3 | 46 | 4.9 |