Cytochrome P450 11B1, mitochondrial · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P15393. Use UniProt P15393 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P15393 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 11B1, mitochondrial
Review this target as Cytochrome P450 11B1, mitochondrial, mapped to UniProt P15393. Sequence length is 499 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 11B1, mitochondrial as ChEMBL target CHEMBL4970, mapped to UniProt P15393. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 11B1, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P15393 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 11B1, mitochondrial |
| UniProt Accession | P15393 |
| Component Type | Protein |
| Sequence Length | 499 aa |
Cytochrome P450 11B1, mitochondrial
Review this target as Cytochrome P450 11B1, mitochondrial, mapped to UniProt P15393. Sequence length is 499 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3099704 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5184829 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL3421769 | 6.79 | IC50 | 163.0 | Preclinical |
| CHEMBL3421770 | 6.43 | IC50 | 370.0 | Preclinical |
| CHEMBL3099696 | 6.41 | IC50 | 386.0 | Preclinical |
| CHEMBL3421780 | 6.36 | IC50 | 441.0 | Preclinical |
| CHEMBL3099695 | 6.3 | IC50 | 495.0 | Approved |
| CHEMBL3421779 | 6.26 | IC50 | 543.0 | Preclinical |
| CHEMBL3421768 | 6.19 | IC50 | 648.0 | Preclinical |
| CHEMBL287677 | 6.16 | IC50 | 686.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 4 | 5.0 |
| cell-based format | 3 | 8 | 6.3 |
| assay format | 1 | 13 | 6.0 |
| tissue-based format | 1 | 3 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 2 | 1 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 1 | 7.6 |