Lanosterol 14-alpha demethylase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q64654. Use UniProt Q64654 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q64654 as the stable identity anchor, then attach disease evidence before program review.
Lanosterol 14-alpha demethylase
Review this target as Lanosterol 14-alpha demethylase, mapped to UniProt Q64654. Sequence length is 503 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lanosterol 14-alpha demethylase as ChEMBL target CHEMBL4981, mapped to UniProt Q64654. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lanosterol 14-alpha demethylase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q64654 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lanosterol 14-alpha demethylase |
| UniProt Accession | Q64654 |
| Component Type | Protein |
| Sequence Length | 503 aa |
Lanosterol 14-alpha demethylase
Review this target as Lanosterol 14-alpha demethylase, mapped to UniProt Q64654. Sequence length is 503 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL70396 | 7.96 | Ki | 11.0 | Preclinical |
| CHEMBL305220 | 7.43 | Ki | 37.0 | Preclinical |
| CHEMBL157101 | 7.33 | IC50 | 47.0 | Approved |
| CHEMBL157101 | 7.19 | Ki | 65.0 | Approved |
| CHEMBL421109 | 6.93 | Ki | 117.0 | Preclinical |
| CHEMBL133834 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL398686 | 6.22 | Ki | 600.0 | Preclinical |
| CHEMBL328863 | 5.86 | IC50 | 1370.0 | Preclinical |
| CHEMBL319160 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL133434 | 5.57 | IC50 | 2700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 3 | 2 | 6.0 |
| assay format | 2 | 4 | 6.3 |
| single protein format | 2 | 5 | 6.8 |