Transient receptor potential cation channel subfamily M member 8 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q8R455. Use UniProt Q8R455 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8R455 as the stable identity anchor, then attach disease evidence before program review.
Transient receptor potential cation channel subfamily M member 8
Review this target as Transient receptor potential cation channel subfamily M member 8, mapped to UniProt Q8R455. Sequence length is 1104 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Transient receptor potential cation channel subfamily M member 8 as ChEMBL target CHEMBL5011, mapped to UniProt Q8R455. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Transient receptor potential cation channel subfamily M member 8 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q8R455 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transient receptor potential cation channel subfamily M member 8 |
| UniProt Accession | Q8R455 |
| Component Type | Protein |
| Sequence Length | 1104 aa |
Transient receptor potential cation channel subfamily M member 8
Review this target as Transient receptor potential cation channel subfamily M member 8, mapped to UniProt Q8R455. Sequence length is 1104 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4295040 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4284808 | 8.46 | IC50 | 3.5 | Preclinical |
| CHEMBL1650511 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3353597 | 8.24 | IC50 | 5.8 | Preclinical |
| CHEMBL4237618 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL3353609 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL4243837 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL4251427 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL4251467 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL2443061 | 7.78 | IC50 | 16.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 50 | 263 | 5.7 |
| single protein format | 2 | 1 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 64 | 6.1 |
| assay format | 1 | 1 | 7.7 |
| organism-based format | 1 | 0 | — |