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Evidence Snapshot

5-hydroxytryptamine receptor 4

CHEMBL5017 SINGLE PROTEIN Cavia porcellus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:22Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5017
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 5-hydroxytryptamine receptor 4 as ChEMBL target CHEMBL5017, mapped to UniProt O70528. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
5-hydroxytryptamine receptor 4
SINGLE PROTEIN · Cavia porcellus
As of 2026-09-13
ChEMBL target ID
CHEMBL5017
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O70528
5-hydroxytryptamine receptor 4
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why 5-hydroxytryptamine receptor 4 matters

As of 2026-09-13

5-hydroxytryptamine receptor 4 is reviewed as 5-hydroxytryptamine receptor 4 (UniProt O70528); the current evidence base includes 29 approved drugs, 1338 compounds, and 140 assays, with lead potency reaching pChEMBL 10.9.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 29 approved drugs, 1338 compounds, and 140 assays for this target. The dominant activity type is KI. CHEMBL68131 is the current potency anchor at pChEMBL 10.9.

Use CHEMBL68131 as the tractability anchor when discussing potency (pChEMBL 10.9).

Activity source · ChEMBL 36 via Core Engine
29 approved pChEMBL 10.9
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why 5-hydroxytryptamine receptor 4 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt O70528, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1338
Total Compounds
140
Total Assays
29
Approved Drugs
IC50: 975.0, KI: 1132.0, EC50: 75.0, KD: 3.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL68131
 10.9 Ki —
No preferred name
CHEMBL68131
 10.7 Kd —
No preferred name
CHEMBL358119
 10.6 IC50 —
No preferred name
CHEMBL68131
 10.1 IC50 —
No preferred name
CHEMBL69733
 10.0 Ki —

Approved Drugs

Structure Compound First Approval
TEGASEROD
CHEMBL76370
 2002
CARVEDILOL
CHEMBL723
 1995
CISAPRIDE
CHEMBL1729
 1993
DOXAZOSIN
CHEMBL707
 1990
METOCLOPRAMIDE
CHEMBL86
 1979
DROPERIDOL
CHEMBL1108
 1970
PROCHLORPERAZINE
CHEMBL728
 1956
ERGOTAMINE
CHEMBL442
 1948
DIHYDROERGOTAMINE
CHEMBL1732
 1946
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:22Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5017