E3 ubiquitin-protein ligase Mdm2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q00987. Use UniProt Q00987 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q00987 as the stable identity anchor, then attach disease evidence before program review.
E3 ubiquitin-protein ligase Mdm2
Review this target as E3 ubiquitin-protein ligase Mdm2, mapped to UniProt Q00987. Sequence length is 491 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats E3 ubiquitin-protein ligase Mdm2 as ChEMBL target CHEMBL5023, mapped to UniProt Q00987. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | E3 ubiquitin-protein ligase Mdm2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q00987 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | E3 ubiquitin-protein ligase Mdm2 |
| UniProt Accession | Q00987 |
| Component Type | Protein |
| Sequence Length | 491 aa |
E3 ubiquitin-protein ligase Mdm2
Review this target as E3 ubiquitin-protein ligase Mdm2, mapped to UniProt Q00987. Sequence length is 491 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3125527 | 10.44 | Kd | 0.036 | Preclinical |
| CHEMBL3125702 | 10.42 | Kd | 0.038 | Clinical |
| CHEMBL3653245 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL4463050 | 10.35 | Ki | 0.045 | Preclinical |
| CHEMBL3657031 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL3657124 | 10.23 | IC50 | 0.059 | Preclinical |
| CHEMBL3318783 | 10.23 | IC50 | 0.059 | Preclinical |
| CHEMBL3318761 | 10.23 | IC50 | 0.059 | Preclinical |
| CHEMBL3691776 | 10.17 | IC50 | 0.068 | Preclinical |
| CHEMBL3639520 | 10.15 | IC50 | 0.07 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 230 | 2,711 | 7.5 |
| cell-based format | 199 | 193 | 6.9 |
| assay format | 80 | 1,961 | 7.7 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 21 | 4.9 |
| assay format | 1 | 167 | 5.5 |
| organism-based format | 1 | 0 | — |