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Target Snapshot

CHEMBL5036 Target Snapshot

cGMP-dependent protein kinase · SINGLE PROTEIN · Eimeria tenella

259Compounds
12Assays
0Approved Drugs
274.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt Q8MMZ8. Use UniProt Q8MMZ8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8MMZ8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats cGMP-dependent protein kinase as ChEMBL target CHEMBL5036, mapped to UniProt Q8MMZ8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
cGMP-dependent protein kinase
SINGLE PROTEIN · Eimeria tenella
As of 2026-09-15
ChEMBL target ID
CHEMBL5036
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
Q8MMZ8
cGMP-dependent protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether cGMP-dependent protein kinase is the right protein anchor across sources, using UniProt Q8MMZ8 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelcGMP-dependent protein kinase
UniProt AccessionQ8MMZ8
Component TypeProtein
Sequence Length1003 aa

cGMP-dependent protein kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as cGMP-dependent protein kinase, mapped to UniProt Q8MMZ8. Sequence length is 1003 aa.

Mapped IDQ8MMZ8
Review namecGMP-dependent protein kinase
OrganismEimeria tenella
Assay Mix

Activity Type Distribution

IC50274.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL250994 10.59 IC50 0.026 Preclinical
CHEMBL207971 10.4 IC50 0.04 Preclinical
CHEMBL497187 10.36 IC50 0.044 Preclinical
CHEMBL207476 10.34 IC50 0.046 Preclinical
CHEMBL370263 10.34 IC50 0.046 Preclinical
CHEMBL428900 10.3 IC50 0.05 Preclinical
CHEMBL248768 10.25 IC50 0.056 Preclinical
CHEMBL233009 10.22 IC50 0.06 Preclinical
CHEMBL250391 10.22 IC50 0.06 Preclinical
CHEMBL400908 10.22 IC50 0.06 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
2
6.0
0
6.5
6
7.0
9
7.5
15
8.0
51
8.5
67
9.0
83
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
256
Tested Compounds
1
Assay Types
Binding — 12 assays, 256 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 12 256 9.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine