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Target Snapshot

CHEMBL5041 Target Snapshot

Beta-lactamase TEM-125 · SINGLE PROTEIN · Escherichia coli

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3Compounds
2Assays
2Approved Drugs
2.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q6GWS8. Use UniProt Q6GWS8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q6GWS8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-lactamase TEM-125 as ChEMBL target CHEMBL5041, mapped to UniProt Q6GWS8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-lactamase TEM-125
SINGLE PROTEIN · Escherichia coli
As of 2026-09-13
ChEMBL target ID
CHEMBL5041
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q6GWS8
Beta-lactamase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-lactamase TEM-125 is the right protein anchor across sources, using UniProt Q6GWS8 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBeta-lactamase TEM-125
Target TypeSINGLE PROTEIN
OrganismEscherichia coli
UniProtQ6GWS8
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-lactamase
UniProt AccessionQ6GWS8
Component TypeProtein
Sequence Length286 aa

Beta-lactamase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Beta-lactamase TEM-125, mapped to UniProt Q6GWS8. ChEMBL maps the protein component as Beta-lactamase. Sequence length is 286 aa.

Mapped IDQ6GWS8
Review nameBeta-lactamase TEM-125
OrganismEscherichia coli
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL404 6.62 IC50 240.0 Approved
CHEMBL777 5.07 IC50 8600.0 Approved
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TAZOBACTAM
CHEMBL404
Approved 1993
Properties Compare Identifier
Assay Landscape

Assay Landscape

2
Total Assays
2
Tested Compounds
1
Assay Types
Binding — 2 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 2 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine