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Target Snapshot

CHEMBL5048 Target Snapshot

Neutral cholesterol ester hydrolase 1 · SINGLE PROTEIN · Homo sapiens

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128Compounds
12Assays
0Approved Drugs
148.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q6PIU2. Use UniProt Q6PIU2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q6PIU2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neutral cholesterol ester hydrolase 1 as ChEMBL target CHEMBL5048, mapped to UniProt Q6PIU2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neutral cholesterol ester hydrolase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5048
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q6PIU2
Neutral cholesterol ester hydrolase 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neutral cholesterol ester hydrolase 1 is the right protein anchor across sources, using UniProt Q6PIU2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeutral cholesterol ester hydrolase 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ6PIU2
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeutral cholesterol ester hydrolase 1
UniProt AccessionQ6PIU2
Component TypeProtein
Sequence Length408 aa

Neutral cholesterol ester hydrolase 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neutral cholesterol ester hydrolase 1, mapped to UniProt Q6PIU2. Sequence length is 408 aa.

Mapped IDQ6PIU2
Review nameNeutral cholesterol ester hydrolase 1
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50148.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2071652 7.3 IC50 50.0 Preclinical
CHEMBL2071655 7.1 IC50 80.0 Preclinical
CHEMBL2069333 7.0 IC50 100.0 Preclinical
CHEMBL2071651 6.89 IC50 130.0 Preclinical
CHEMBL2071650 6.82 IC50 150.0 Preclinical
CHEMBL2071653 6.82 IC50 150.0 Preclinical
CHEMBL2071654 6.82 IC50 150.0 Preclinical
CHEMBL2071649 6.51 IC50 310.0 Preclinical
CHEMBL2071641 6.48 IC50 330.0 Preclinical
CHEMBL2071656 6.48 IC50 330.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
10
5.5
6
6.0
6
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
49
Tested Compounds
1
Assay Types
Binding — 12 assays, 49 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 36 5.7
single protein format 5 13 4.6
subcellular format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine