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Target Snapshot

CHEMBL5058625 Target Snapshot

AML12 · CELL-LINE · Mus musculus

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201Compounds
78Assays
1Approved Drugs
46.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats AML12 as ChEMBL target CHEMBL5058625. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
AML12
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL5058625
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether AML12 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAML12
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAML12
UniProt AccessionN/A

AML12

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as AML12.

Review nameAML12
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5042.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5571421 8.05 EC50 9.0 Preclinical
CHEMBL3633556 6.98 EC50 104.0 Preclinical
CHEMBL2103863 5.74 IC50 1820.0 Clinical
CHEMBL5417311 5.53 IC50 2940.0 Preclinical
CHEMBL5423299 5.49 IC50 3270.0 Preclinical
CHEMBL5409565 5.48 IC50 3300.0 Preclinical
CHEMBL5420243 5.47 IC50 3400.0 Preclinical
CHEMBL5419989 5.43 IC50 3690.0 Preclinical
CHEMBL556 5.05 EC50 8830.0 Approved
Distribution

pChEMBL Value Distribution

5
5.0
2
5.5
1
6.0
1
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

78
Total Assays
6
Tested Compounds
3
Assay Types
Functional — 59 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 59 3 6.6
Toxicity — 15 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 6 5.5
ADME — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine