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Target Snapshot

CHEMBL5058627 Target Snapshot

Mesenchymal stem cells · CELL-LINE · Homo sapiens

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151Compounds
62Assays
3Approved Drugs
63.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mesenchymal stem cells as ChEMBL target CHEMBL5058627. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mesenchymal stem cells
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5058627
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mesenchymal stem cells still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameMesenchymal stem cells
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMesenchymal stem cells
UniProt AccessionN/A

Mesenchymal stem cells

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Mesenchymal stem cells.

Review nameMesenchymal stem cells
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5042.0
EC5021.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL408 7.0 EC50 100.0 Approved
CHEMBL4758598 6.22 IC50 600.0 Preclinical
CHEMBL4763181 6.16 IC50 700.0 Preclinical
CHEMBL301982 6.16 IC50 700.0 Preclinical
CHEMBL595 6.1 EC50 790.0 Approved
CHEMBL4782984 6.1 IC50 800.0 Preclinical
CHEMBL5291409 6.05 IC50 900.0 Preclinical
CHEMBL5275224 6.05 IC50 900.0 Preclinical
CHEMBL4789502 6.05 IC50 900.0 Preclinical
CHEMBL1170915 6.0 IC50 1000.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
29
5.5
12
6.0
0
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PIOGLITAZONE
CHEMBL595
Approved 1999
Properties Compare Identifier
TROGLITAZONE
CHEMBL408
Approved 1997
Properties Compare Identifier
Assay Landscape

Assay Landscape

62
Total Assays
42
Tested Compounds
3
Assay Types
Functional — 52 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 52 16 5.1
Toxicity — 8 assays, 42 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 42 5.7
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine