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Target Snapshot

CHEMBL5070 Target Snapshot

Beta-ketoacyl-[acyl-carrier-protein] synthase III · SINGLE PROTEIN · Enterococcus faecalis (strain ATCC 700802 / V583)

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51Compounds
2Assays
0Approved Drugs
89.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q820T1. Use UniProt Q820T1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q820T1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-ketoacyl-[acyl-carrier-protein] synthase III as ChEMBL target CHEMBL5070, mapped to UniProt Q820T1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-ketoacyl-[acyl-carrier-protein] synthase III
SINGLE PROTEIN · Enterococcus faecalis (strain ATCC 700802 / V583)
As of 2026-09-14
ChEMBL target ID
CHEMBL5070
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q820T1
Beta-ketoacyl-[acyl-carrier-protein] synthase III
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-ketoacyl-[acyl-carrier-protein] synthase III is the right protein anchor across sources, using UniProt Q820T1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBeta-ketoacyl-[acyl-carrier-protein] synthase III
Target TypeSINGLE PROTEIN
OrganismEnterococcus faecalis (strain ATCC 700802 / V583)
UniProtQ820T1
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-ketoacyl-[acyl-carrier-protein] synthase III
UniProt AccessionQ820T1
Component TypeProtein
Sequence Length321 aa

Beta-ketoacyl-[acyl-carrier-protein] synthase III

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Beta-ketoacyl-[acyl-carrier-protein] synthase III, mapped to UniProt Q820T1. Sequence length is 321 aa.

Mapped IDQ820T1
Review nameBeta-ketoacyl-[acyl-carrier-protein] synthase III
OrganismEnterococcus faecalis (strain ATCC 700802 / V583)
Assay Mix

Activity Type Distribution

IC5089.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL370931 8.4 IC50 4.0 Preclinical
CHEMBL499343 8.4 IC50 3.999 Preclinical
CHEMBL180466 7.55 IC50 28.0 Preclinical
CHEMBL175848 7.25 IC50 55.98 Preclinical
CHEMBL191827 7.21 IC50 62.0 Preclinical
CHEMBL499342 7.21 IC50 62.09 Preclinical
CHEMBL179596 7.02 IC50 95.94 Preclinical
CHEMBL179595 6.96 IC50 109.9 Preclinical
CHEMBL180271 6.8 IC50 160.0 Preclinical
CHEMBL195658 6.8 IC50 160.0 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
18
5.5
12
6.0
16
6.5
6
7.0
2
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
50
Tested Compounds
1
Assay Types
Binding — 2 assays, 50 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 50 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine