Prostaglandin D2 receptor 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Prostaglandin D2 receptor 2 shows late clinical disease relevance led by asthma. 5 more disease programs remain visible in the same review block. 11 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9Y5Y4. Start with asthma, then reuse UniProt Q9Y5Y4 as the stable protein anchor across project notes and exports.
Start with asthma, then reuse UniProt Q9Y5Y4 as the stable protein anchor across project notes and exports.
Prostaglandin D2 receptor 2 shows late clinical disease relevance led by asthma. 5 more disease programs remain visible in the same review block. 11 linked drugs remain visible in the same block.
Start review with asthma because it currently carries late clinical support. Linked drugs include ADC3680, ARRY-502, AZD1981, BI-671800. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProstaglandin D2 receptor 2
Review this target as Prostaglandin D2 receptor 2, mapped to UniProt Q9Y5Y4. Sequence length is 395 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prostaglandin D2 receptor 2 as ChEMBL target CHEMBL5071, mapped to UniProt Q9Y5Y4. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Prostaglandin D2 receptor 2 is the right protein anchor across sources, using UniProt Q9Y5Y4 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why asthma is currently framed as late clinical support. It currently carries 11 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Prostaglandin D2 receptor 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y5Y4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin D2 receptor 2 |
| UniProt Accession | Q9Y5Y4 |
| Component Type | Protein |
| Sequence Length | 395 aa |
Prostaglandin D2 receptor 2
Review this target as Prostaglandin D2 receptor 2, mapped to UniProt Q9Y5Y4. Sequence length is 395 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Prostaglandin D2 receptor 2 shows late clinical disease relevance led by asthma. 5 more disease programs remain visible in the same review block.
Start review with asthma because it currently carries late clinical support. Linked drugs include ADC3680, ARRY-502, AZD1981, BI-671800. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1088284 | 10.92 | IC50 | 0.012 | Preclinical |
| CHEMBL2181748 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL1081033 | 10.14 | IC50 | 0.072 | Preclinical |
| CHEMBL1087029 | 10.1 | IC50 | 0.079 | Preclinical |
| CHEMBL1087622 | 10.07 | IC50 | 0.085 | Preclinical |
| CHEMBL1080695 | 10.01 | IC50 | 0.098 | Preclinical |
| CHEMBL2181751 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3639847 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3667662 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL1778632 | 10.0 | IC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 82 | 1,533 | 7.5 |
| single protein format | 54 | 290 | 7.6 |
| assay format | 17 | 1,249 | 7.4 |
| tissue-based format | 3 | 2 | 8.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 94 | 778 | 7.2 |
| assay format | 26 | 67 | 7.8 |
| tissue-based format | 6 | 25 | 7.5 |
| cell-free format | 1 | 4 | 7.7 |
| single protein format | 1 | 13 | 7.1 |