Use UniProt Q8IU85 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL5073 Target Snapshot
Calcium/calmodulin-dependent protein kinase type 1D · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8IU85. Use UniProt Q8IU85 as the stable identity anchor, then attach disease evidence before program review.
Calcium/calmodulin-dependent protein kinase type 1D
Review this target as Calcium/calmodulin-dependent protein kinase type 1D, mapped to UniProt Q8IU85. Sequence length is 385 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Calcium/calmodulin-dependent protein kinase type 1D as ChEMBL target CHEMBL5073, mapped to UniProt Q8IU85. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Calcium/calmodulin-dependent protein kinase type 1D |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8IU85 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Calcium/calmodulin-dependent protein kinase type 1D |
| UniProt Accession | Q8IU85 |
| Component Type | Protein |
| Sequence Length | 385 aa |
Calcium/calmodulin-dependent protein kinase type 1D
How to read this target
Review this target as Calcium/calmodulin-dependent protein kinase type 1D, mapped to UniProt Q8IU85. Sequence length is 385 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.69 | IC50 | 0.206 | Preclinical |
| CHEMBL388978 | 8.96 | Kd | 1.1 | Preclinical |
| CHEMBL5753821 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL6043667 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL1980995 | 8.4 | Ki | 3.981 | Preclinical |
| CHEMBL5826196 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL5918789 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL5826007 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5996247 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL6050954 | 8.22 | IC50 | 6.0 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 272 assays, 178 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 209 | 158 | 7.0 |
| assay format | 27 | 15 | 6.9 |
| subcellular format | 20 | 0 | — |
| cell-based format | 16 | 5 | 7.6 |
Functional — 2 assays, 90 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 89 | 5.6 |
| cell-based format | 1 | 1 | 8.0 |