Histamine H3 receptor · SINGLE PROTEIN · Cavia porcellus
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As of 2026-09-13Protein identity stays anchored to UniProt Q9JI35. Use UniProt Q9JI35 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9JI35 as the stable identity anchor, then attach disease evidence before program review.
Histamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt Q9JI35. Sequence length is 445 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H3 receptor as ChEMBL target CHEMBL5076, mapped to UniProt Q9JI35. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histamine H3 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
| UniProt | Q9JI35 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H3 receptor |
| UniProt Accession | Q9JI35 |
| Component Type | Protein |
| Sequence Length | 445 aa |
Histamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt Q9JI35. Sequence length is 445 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL371730 | 10.1 | Kd | 0.07943 | Preclinical |
| CHEMBL268229 | 10.07 | Ki | 0.08511 | Preclinical |
| CHEMBL200382 | 9.9 | Kd | 0.1259 | Preclinical |
| CHEMBL90 | 9.84 | Ki | 0.1445 | Approved |
| CHEMBL1222863 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL14690 | 9.8 | Kd | 0.1585 | Preclinical |
| CHEMBL373000 | 9.8 | Kd | 0.1585 | Preclinical |
| CHEMBL462605 | 9.8 | Ki | 0.16 | Approved |
| CHEMBL1222800 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL1222865 | 9.7 | Kd | 0.1995 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 55 | 195 | 7.5 |
| assay format | 10 | 6 | 7.0 |
| cell-based format | 2 | 1 | 9.3 |
| organism-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 33 | 177 | 7.7 |
| assay format | 13 | 151 | 7.8 |
| single protein format | 11 | 74 | 7.7 |
| cell membrane format | 3 | 30 | 7.5 |