Interleukin-1 receptor-associated kinase 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9Y616. Use UniProt Q9Y616 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y616 as the stable identity anchor, then attach disease evidence before program review.
Interleukin-1 receptor-associated kinase 3
Review this target as Interleukin-1 receptor-associated kinase 3, mapped to UniProt Q9Y616. Sequence length is 596 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Interleukin-1 receptor-associated kinase 3 as ChEMBL target CHEMBL5081, mapped to UniProt Q9Y616. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Interleukin-1 receptor-associated kinase 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y616 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Interleukin-1 receptor-associated kinase 3 |
| UniProt Accession | Q9Y616 |
| Component Type | Protein |
| Sequence Length | 596 aa |
Interleukin-1 receptor-associated kinase 3
Review this target as Interleukin-1 receptor-associated kinase 3, mapped to UniProt Q9Y616. Sequence length is 596 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4763746 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4788568 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4749646 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL4744403 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL4777817 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL4798668 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL3301622 | 8.15 | Kd | 7.0 | Approved |
| CHEMBL4094760 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4779593 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL475251 | 7.96 | Kd | 11.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 81 | 34 | 6.2 |
| assay format | 27 | 4 | 6.3 |
| subcellular format | 13 | 27 | 6.5 |
| cell-based format | 5 | 24 | 7.8 |