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Target Snapshot

CHEMBL5094 Target Snapshot

Beta-lactamase SHV-1 · SINGLE PROTEIN · Klebsiella pneumoniae

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21Compounds
23Assays
2Approved Drugs
7.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Beta-lactamase SHV-1 shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P0AD64. Start with infection, then reuse UniProt P0AD64 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with infection, then reuse UniProt P0AD64 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
infection

Beta-lactamase SHV-1 shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with infection because it currently carries approved-linked support. Linked drugs include RELEBACTAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-lactamase SHV-1 as ChEMBL target CHEMBL5094, mapped to UniProt P0AD64. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-lactamase SHV-1
SINGLE PROTEIN · Klebsiella pneumoniae
As of 2026-09-13
ChEMBL target ID
CHEMBL5094
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P0AD64
Beta-lactamase SHV-1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-lactamase SHV-1 is the right protein anchor across sources, using UniProt P0AD64 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why infection is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBeta-lactamase SHV-1
Target TypeSINGLE PROTEIN
OrganismKlebsiella pneumoniae
UniProtP0AD64
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-lactamase SHV-1
UniProt AccessionP0AD64
Component TypeProtein
Sequence Length286 aa

Beta-lactamase SHV-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Beta-lactamase SHV-1, mapped to UniProt P0AD64. Sequence length is 286 aa.

Mapped IDP0AD64
Review nameBeta-lactamase SHV-1
OrganismKlebsiella pneumoniae
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Beta-lactamase SHV-1 shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
infection
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Approved-linked Approved
pyelonephritis
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Approved-linked Approved
urinary tract infection
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Late clinical Phase III
bacterial disease
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Late clinical Phase III
bacterial pneumonia
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Clinical signal Phase II
hematopoietic and lymphoid cell neoplasm
1 linked drug · 1 direct · 1 efficacy
Linked drugRELEBACTAM
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with infection because it currently carries approved-linked support. Linked drugs include RELEBACTAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseinfection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC503.0
KI4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL404 6.96 IC50 110.0 Approved
CHEMBL777 6.77 IC50 170.0 Approved
CHEMBL2236666 5.37 Ki 4230.0 Preclinical
CHEMBL1673092 4.17 Ki 67890.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
3
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TAZOBACTAM
CHEMBL404
Approved 1993
Properties Compare Identifier
CLAVULANIC ACID
CHEMBL777
Approved 1984
Properties Compare Identifier
Assay Landscape

Assay Landscape

23
Total Assays
5
Tested Compounds
1
Assay Types
Binding — 23 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 23 5 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine