3-oxo-5-alpha-steroid 4-dehydrogenase 2 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P31214. Use UniProt P31214 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31214 as the stable identity anchor, then attach disease evidence before program review.
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Review this target as 3-oxo-5-alpha-steroid 4-dehydrogenase 2, mapped to UniProt P31214. Sequence length is 254 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 3-oxo-5-alpha-steroid 4-dehydrogenase 2 as ChEMBL target CHEMBL5099, mapped to UniProt P31214. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P31214 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
| UniProt Accession | P31214 |
| Component Type | Protein |
| Sequence Length | 254 aa |
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Review this target as 3-oxo-5-alpha-steroid 4-dehydrogenase 2, mapped to UniProt P31214. Sequence length is 254 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL314953 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL277224 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL710 | 9.55 | IC50 | 0.28 | Approved |
| CHEMBL327702 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL5190333 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4540042 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4569322 | 7.47 | IC50 | 34.0 | Preclinical |
| CHEMBL115438 | 7.42 | IC50 | 38.0 | Preclinical |
| CHEMBL424066 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL1778071 | 7.06 | IC50 | 87.98 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 6 | 8.2 |
| assay format | 3 | 3 | 7.6 |
| microsome format | 1 | 2 | 7.7 |
| tissue-based format | 1 | 11 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 5 | 6.4 |