Transient receptor potential cation channel subfamily V member 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt O35433. Use UniProt O35433 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O35433 as the stable identity anchor, then attach disease evidence before program review.
Transient receptor potential cation channel subfamily V member 1
Review this target as Transient receptor potential cation channel subfamily V member 1, mapped to UniProt O35433. Sequence length is 838 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Transient receptor potential cation channel subfamily V member 1 as ChEMBL target CHEMBL5102, mapped to UniProt O35433. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Transient receptor potential cation channel subfamily V member 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | O35433 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transient receptor potential cation channel subfamily V member 1 |
| UniProt Accession | O35433 |
| Component Type | Protein |
| Sequence Length | 838 aa |
Transient receptor potential cation channel subfamily V member 1
Review this target as Transient receptor potential cation channel subfamily V member 1, mapped to UniProt O35433. Sequence length is 838 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL17976 | 10.7 | Ki | 0.02 | Clinical |
| CHEMBL2414497 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL104647 | 10.27 | Ki | 0.054 | Preclinical |
| CHEMBL4060041 | 10.19 | Kd | 0.064 | Preclinical |
| CHEMBL455580 | 10.16 | IC50 | 0.069 | Preclinical |
| CHEMBL504725 | 10.14 | Ki | 0.073 | Preclinical |
| CHEMBL3689037 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3689046 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL4125690 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL6042549 | 10.0 | IC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 138 | 772 | 6.8 |
| single protein format | 36 | 134 | 7.2 |
| assay format | 10 | 378 | 6.5 |
| tissue-based format | 6 | 15 | 8.0 |
| cell membrane format | 4 | 13 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 113 | 658 | 7.2 |
| assay format | 19 | 113 | 6.8 |
| tissue-based format | 10 | 27 | 6.5 |
| organism-based format | 4 | 0 | — |