Polyamine deacetylase HDAC10 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q969S8. Use UniProt Q969S8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q969S8 as the stable identity anchor, then attach disease evidence before program review.
Polyamine deacetylase HDAC10
Review this target as Polyamine deacetylase HDAC10, mapped to UniProt Q969S8. Sequence length is 669 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Polyamine deacetylase HDAC10 as ChEMBL target CHEMBL5103, mapped to UniProt Q969S8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Polyamine deacetylase HDAC10 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q969S8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polyamine deacetylase HDAC10 |
| UniProt Accession | Q969S8 |
| Component Type | Protein |
| Sequence Length | 669 aa |
Polyamine deacetylase HDAC10
Review this target as Polyamine deacetylase HDAC10, mapped to UniProt Q969S8. Sequence length is 669 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2105763 | 10.3 | Ki | 0.05 | Clinical |
| CHEMBL3329621 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL2105763 | 9.34 | IC50 | 0.46 | Clinical |
| CHEMBL1796689 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL3329622 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL3593247 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL4532398 | 9.24 | IC50 | 0.58 | Preclinical |
| CHEMBL3827517 | 9.07 | IC50 | 0.86 | Preclinical |
| CHEMBL343448 | 9.05 | IC50 | 0.9 | Approved |
| CHEMBL5618885 | 9.05 | IC50 | 0.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 222 | 371 | 6.6 |
| cell-based format | 37 | 94 | 6.8 |
| assay format | 10 | 8 | 5.9 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 4 | 5.3 |
| cell-based format | 1 | 2 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 5.4 |