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Target Snapshot

CHEMBL5107 Target Snapshot

Voltage-dependent N-type calcium channel subunit alpha-1B · SINGLE PROTEIN · Rattus norvegicus

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424Compounds
40Assays
0Approved Drugs
121.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt Q02294. Use UniProt Q02294 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q02294 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Voltage-dependent N-type calcium channel subunit alpha-1B as ChEMBL target CHEMBL5107, mapped to UniProt Q02294. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Voltage-dependent N-type calcium channel subunit alpha-1B
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-15
ChEMBL target ID
CHEMBL5107
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
Q02294
Voltage-dependent N-type calcium channel subunit alpha-1B
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Voltage-dependent N-type calcium channel subunit alpha-1B is the right protein anchor across sources, using UniProt Q02294 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameVoltage-dependent N-type calcium channel subunit alpha-1B
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtQ02294
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVoltage-dependent N-type calcium channel subunit alpha-1B
UniProt AccessionQ02294
Component TypeProtein
Sequence Length2336 aa

Voltage-dependent N-type calcium channel subunit alpha-1B

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Voltage-dependent N-type calcium channel subunit alpha-1B, mapped to UniProt Q02294. Sequence length is 2336 aa.

Mapped IDQ02294
Review nameVoltage-dependent N-type calcium channel subunit alpha-1B
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5092.0
EC5029.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2047726 7.39 IC50 40.74 Preclinical
CHEMBL597585 7.13 IC50 74.0 Preclinical
CHEMBL597788 6.98 IC50 105.0 Preclinical
CHEMBL3930176 6.96 IC50 111.0 Preclinical
CHEMBL3927466 6.94 IC50 114.0 Preclinical
CHEMBL3978555 6.92 IC50 120.0 Preclinical
CHEMBL596946 6.92 IC50 120.0 Preclinical
CHEMBL3939633 6.86 IC50 137.0 Preclinical
CHEMBL3915774 6.85 IC50 140.0 Preclinical
CHEMBL598806 6.77 IC50 170.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
7
5.5
23
6.0
36
6.5
4
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

40
Total Assays
76
Tested Compounds
2
Assay Types
Binding — 39 assays, 76 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 17 52 6.2
single protein format 13 10 4.9
assay format 7 2 5.2
cell membrane format 1 0 —
tissue-based format 1 12 4.6
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine