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Target Snapshot

CHEMBL5114 Target Snapshot

Quinolone resistance protein NorA · SINGLE PROTEIN · Staphylococcus aureus

765Compounds
322Assays
5Approved Drugs
168.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0A0J7. Use UniProt P0A0J7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0A0J7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Quinolone resistance protein NorA as ChEMBL target CHEMBL5114, mapped to UniProt P0A0J7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Quinolone resistance protein NorA
SINGLE PROTEIN · Staphylococcus aureus
As of 2026-09-14
ChEMBL target ID
CHEMBL5114
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0A0J7
Quinolone resistance protein NorA
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Quinolone resistance protein NorA is the right protein anchor across sources, using UniProt P0A0J7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelQuinolone resistance protein NorA
UniProt AccessionP0A0J7
Component TypeProtein
Sequence Length388 aa

Quinolone resistance protein NorA

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Quinolone resistance protein NorA, mapped to UniProt P0A0J7. Sequence length is 388 aa.

Mapped IDP0A0J7
Review nameQuinolone resistance protein NorA
OrganismStaphylococcus aureus
Clinical Profile

Clinical Phase Distribution

5
Approved
Assay Mix

Activity Type Distribution

IC50168.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4171147 5.96 IC50 1100.0 Preclinical
CHEMBL4175014 5.8 IC50 1600.0 Preclinical
CHEMBL3929187 5.75 IC50 1800.0 Preclinical
CHEMBL4172225 5.75 IC50 1800.0 Preclinical
CHEMBL1642586 5.7 IC50 2000.0 Preclinical
CHEMBL3956740 5.7 IC50 2020.0 Preclinical
CHEMBL4071003 5.7 IC50 2000.0 Preclinical
CHEMBL4177330 5.66 IC50 2200.0 Preclinical
CHEMBL4163342 5.55 IC50 2800.0 Preclinical
CHEMBL4164053 5.48 IC50 3300.0 Preclinical
Distribution

pChEMBL Value Distribution

81
5.0
9
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

322
Total Assays
114
Tested Compounds
1
Assay Types
Binding — 322 assays, 114 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 240 109 5.1
assay format 74 5 4.9
cell-based format 8 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine