Cytochrome P450 26A1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Cytochrome P450 26A1 shows clinical signal disease relevance led by acne. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O43174. Start with acne, then reuse UniProt O43174 as the stable protein anchor across project notes and exports.
Start with acne, then reuse UniProt O43174 as the stable protein anchor across project notes and exports.
Cytochrome P450 26A1 shows clinical signal disease relevance led by acne. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with acne because it currently carries clinical signal support. Linked drugs include TALAROZOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCytochrome P450 26A1
Review this target as Cytochrome P450 26A1, mapped to UniProt O43174. Sequence length is 497 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 26A1 as ChEMBL target CHEMBL5141, mapped to UniProt O43174. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Cytochrome P450 26A1 is the right protein anchor across sources, using UniProt O43174 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acne is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Cytochrome P450 26A1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O43174 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 26A1 |
| UniProt Accession | O43174 |
| Component Type | Protein |
| Sequence Length | 497 aa |
Cytochrome P450 26A1
Review this target as Cytochrome P450 26A1, mapped to UniProt O43174. Sequence length is 497 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Cytochrome P450 26A1 shows clinical signal disease relevance led by acne. 2 more disease programs remain visible in the same review block.
Start review with acne because it currently carries clinical signal support. Linked drugs include TALAROZOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1831092 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL1831083 | 9.46 | IC50 | 0.35 | Preclinical |
| CHEMBL208443 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL205862 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL207304 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL57765 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL1766005 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL1766007 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL207486 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL368448 | 8.48 | IC50 | 3.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 16 | 89 | 5.7 |
| single protein format | 8 | 62 | 6.8 |
| microsome format | 4 | 36 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 25 | 7.5 |
| microsome format | 1 | 4 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 22 | 4.9 |