Trypanothione reductase · SINGLE PROTEIN · Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q389T8. Use UniProt Q389T8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q389T8 as the stable identity anchor, then attach disease evidence before program review.
Trypanothione reductase
Review this target as Trypanothione reductase, mapped to UniProt Q389T8. Sequence length is 492 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Trypanothione reductase as ChEMBL target CHEMBL5154, mapped to UniProt Q389T8. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Trypanothione reductase is the right protein anchor across sources, using UniProt Q389T8 as the stable mapping.
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| Preferred Name | Trypanothione reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) |
| UniProt | Q389T8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Trypanothione reductase |
| UniProt Accession | Q389T8 |
| Component Type | Protein |
| Sequence Length | 492 aa |
Trypanothione reductase
Review this target as Trypanothione reductase, mapped to UniProt Q389T8. Sequence length is 492 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL612055 | 4.84 | IC50 | 14600.0 | Preclinical |
| CHEMBL609096 | 4.5 | IC50 | 31900.0 | Preclinical |
| CHEMBL608849 | 4.44 | IC50 | 36000.0 | Preclinical |
| CHEMBL612047 | 4.43 | IC50 | 37300.0 | Preclinical |
| CHEMBL608846 | 4.33 | IC50 | 46900.0 | Preclinical |
| CHEMBL73451 | 4.26 | IC50 | 54300.0 | Clinical |
| CHEMBL492346 | 4.23 | IC50 | 58700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 7 | 4.4 |